ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.

نویسندگان

  • Sue Hyun Lee
  • Timothy C Boire
  • Jung Bok Lee
  • Mukesh K Gupta
  • Angela L Zachman
  • Rutwik Rath
  • Hak-Joon Sung
چکیده

A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis in vivo, indicating its unique advantages for tissue engineering applications.

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عنوان ژورنال:
  • Journal of materials chemistry. B

دوره 2 41  شماره 

صفحات  -

تاریخ انتشار 2014